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TWF2

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GENERAL INFORMATION

Gene name

 TWF2

Gene description

 Twinfilin actin binding protein 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA053874
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053874 U-2 OS Plasma membrane
HPA053874 U-251 MG Plasma membrane

GENE INFORMATION

Gene name

 TWF2 (HGNC Symbol)

Synonyms

 A6r, A6RP, PTK9L

Description

 Twinfilin actin binding protein 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.2

Chromosome location (bp)

 52228610 - 52239260

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000247596 (version 83.38)

Entrez gene

 11344

UniProt

 Q6IBS0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6IBS0

Antibodypedia

 TWF2 antibodies

PROTEIN BROWSER
TWF2-001
TWF2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TWF2-001
ENSP00000303908
ENST00000305533
Q6IBS0 [Direct mapping]
Twinfilin-2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0003785 [actin monomer binding]
GO:0005080 [protein kinase C binding]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010976 [positive regulation of neuron projection development]
GO:0030016 [myofibril]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032420 [stereocilium]
GO:0032532 [regulation of microvillus length]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0042989 [sequestering of actin monomers]
GO:0044822 [poly(A) RNA binding]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0071300 [cellular response to retinoic acid]
GO:0071363 [cellular response to growth factor stimulus]
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 349 aa
39.5 kDa 		No 0
TWF2-005
ENSP00000426464
ENST00000499914
D6RG15 [Direct mapping]
Twinfilin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0030837 [negative regulation of actin filament polymerization]
Show all
 254 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.