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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TWF2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TWF2

Gene description

Twinfilin actin binding protein 2

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression, mainly expressed in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA053874
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA053874

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several lymphomas, few pancreatic cancers along with occasional cases of breast, ovarian and endometrial cancers showed weak to moderate cytoplasmic positivity. Other cancer tissues were generally negative.

GENE INFORMATION

Gene name

TWF2 (HGNC Symbol)

Synonyms

A6r, A6RP, PTK9L

Description

Twinfilin actin binding protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p21.2

Chromosome location (bp)

52228610 - 52239260

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000247596 (version 83.38)

Entrez gene

11344

UniProt

Q6IBS0 (UniProt - Evidence at protein level)

neXtProt

NX_Q6IBS0

Antibodypedia

TWF2 antibodies

PROTEIN BROWSER

TWF2-001
TWF2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TWF2-001
ENSP00000303908
ENST00000305533
Q6IBS0 [Direct mapping]
Twinfilin-2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0003785 [actin monomer binding]
GO:0005080 [protein kinase C binding]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010976 [positive regulation of neuron projection development]
GO:0030016 [myofibril]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032420 [stereocilium]
GO:0032532 [regulation of microvillus length]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0042989 [sequestering of actin monomers]
GO:0044822 [poly(A) RNA binding]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0071300 [cellular response to retinoic acid]
GO:0071363 [cellular response to growth factor stimulus]
Show all
349 aa
39.5 kDa
No 0
TWF2-005
ENSP00000426464
ENST00000499914
D6RG15 [Direct mapping]
Twinfilin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0030837 [negative regulation of actin filament polymerization]
Show all
254 aa
28.9 kDa
No 0

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