Cell atlas - MARS2 - The Human Protein Atlas

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MARS2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Intermediate filaments

Human cell
	Cytosol
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	MARS2
Gene description	Methionyl-tRNA synthetase 2, mitochondrial
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & intermediate filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035589
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & intermediate filaments.

Main location

Intermediate filaments (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035589	U-2 OS	Intermediate filaments
	HPA035589	U-2 OS	Aggresome
	HPA035589	U-251 MG	Intermediate filaments
	HPA035589	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MARS2 (HGNC Symbol)
Synonyms	mtMetRS, SPAX3
Description	Methionyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). [provided by RefSeq, Apr 2014]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	197705369 - 197708387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000247626 (version 83.38)
Entrez gene	92935
UniProt	Q96GW9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96GW9
Antibodypedia	MARS2 antibodies

PROTEIN BROWSER

MARS2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARS2-001 ENSP00000282276 ENST00000282276	Q96GW9 [Direct mapping] Methionine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004825 [methionine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006431 [methionyl-tRNA aminoacylation] GO:0010467 [gene expression] Show all	593 aa 66.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.