Fields »
ABOUT
HELP
BLOG
MARS2

GENERAL INFORMATION

Gene name

 MARS2

Gene description

 Methionyl-tRNA synthetase 2, mitochondrial

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA035589 , HPA035590
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), glioma (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Glioma p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA035589
HPA035590

GENE INFORMATION

Gene name

 MARS2 (HGNC Symbol)

Synonyms

 mtMetRS, SPAX3

Description

 Methionyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). [provided by RefSeq, Apr 2014]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 197705369 - 197708387

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000247626 (version 83.38)

Entrez gene

 92935

UniProt

 Q96GW9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96GW9

Antibodypedia

 MARS2 antibodies

PROTEIN BROWSER
MARS2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MARS2-001
ENSP00000282276
ENST00000282276
Q96GW9 [Direct mapping]
Methionine--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004825 [methionine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006431 [methionyl-tRNA aminoacylation]
GO:0010467 [gene expression]
Show all
 593 aa
66.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.