Cell atlas - INSL3 - The Human Protein Atlas

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INSL3

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	INSL3
Gene description	Insulin-like 3 (Leydig cell)
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SCLC-21H, SH-SY5Y, Karpas-707)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, SH-SY5Y, Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	INSL3 (HGNC Symbol)
Synonyms	MGC119818, MGC119819, RLF, RLNL
Description	Insulin-like 3 (Leydig cell) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17816512 - 17821574
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000248099 (version 83.38)
Entrez gene	3640
UniProt	P51460 (UniProt - Evidence at protein level)
neXtProt	NX_P51460
Antibodypedia	INSL3 antibodies

PROTEIN BROWSER

INSL3-001	INSL3-002	INSL3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INSL3-001 ENSP00000321724 ENST00000317306	P51460 [Direct mapping] Insulin-like 3 Insulin-like 3 B chain Insulin-like 3 A chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0002020 [protease binding] GO:0005102 [receptor binding] GO:0005158 [insulin receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0007267 [cell-cell signaling] GO:0007283 [spermatogenesis] GO:0010634 [positive regulation of epithelial cell migration] GO:0090303 [positive regulation of wound healing] Show all	131 aa 14.5 kDa	Yes	0
INSL3-002 ENSP00000369017 ENST00000379695	P51460 [Direct mapping] Insulin-like 3 Insulin-like 3 B chain Insulin-like 3 A chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001556 [oocyte maturation] GO:0001664 [G-protein coupled receptor binding] GO:0001701 [in utero embryonic development] GO:0002020 [protease binding] GO:0005102 [receptor binding] GO:0005158 [insulin receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007283 [spermatogenesis] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010634 [positive regulation of epithelial cell migration] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0043066 [negative regulation of apoptotic process] GO:0048471 [perinuclear region of cytoplasm] GO:0090303 [positive regulation of wound healing] Show all	157 aa 16.9 kDa	Yes	0
INSL3-003 ENSP00000469309 ENST00000598577	M0QXQ3 [Direct mapping] Insulin-like 3 Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	71 aa 7.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.