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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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INSL3
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

INSL3

Gene description

Insulin-like 3 (Leydig cell)

Protein class

Disease related genes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Cell line enhanced (Karpas-707, SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in Leydig cells in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA028615
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA028615

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All malignant cells were negative.

GENE INFORMATION

Gene name

INSL3 (HGNC Symbol)

Synonyms

MGC119818, MGC119819, RLF, RLNL

Description

Insulin-like 3 (Leydig cell) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

17816512 - 17821574

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000248099 (version 83.38)

Entrez gene

3640

UniProt

P51460 (UniProt - Evidence at protein level)

neXtProt

NX_P51460

Antibodypedia

INSL3 antibodies

PROTEIN BROWSER

INSL3-001
INSL3-002
INSL3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INSL3-001
ENSP00000321724
ENST00000317306
P51460 [Direct mapping]
Insulin-like 3 Insulin-like 3 B chain Insulin-like 3 A chain
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005102 [receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0007267 [cell-cell signaling]
GO:0007283 [spermatogenesis]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0090303 [positive regulation of wound healing]
Show all
131 aa
14.5 kDa
Yes 0
INSL3-002
ENSP00000369017
ENST00000379695
P51460 [Direct mapping]
Insulin-like 3 Insulin-like 3 B chain Insulin-like 3 A chain
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0001556 [oocyte maturation]
GO:0001664 [G-protein coupled receptor binding]
GO:0001701 [in utero embryonic development]
GO:0002020 [protease binding]
GO:0005102 [receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007283 [spermatogenesis]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008584 [male gonad development]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090303 [positive regulation of wound healing]
Show all
157 aa
16.9 kDa
Yes 0
INSL3-003
ENSP00000469309
ENST00000598577
M0QXQ3 [Direct mapping]
Insulin-like 3
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
71 aa
7.6 kDa
Yes 0

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