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ADH1C

GENERAL INFORMATION

Gene name

 ADH1C

Gene description

 Alcohol dehydrogenase 1C (class I), gamma polypeptide

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (A549, ASC TERT1)
HPA (normal tissue):Tissue enhanced (duodenum, liver, stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in glandular cells of gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA047814 , HPA060902
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable) and liver cancer (favourable).
Lung cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA047814
HPA060902

GENE INFORMATION

Gene name

 ADH1C (HGNC Symbol)

Synonyms

 ADH3

Description

 Alcohol dehydrogenase 1C (class I), gamma polypeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 99336492 - 99353027

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000248144 (version 83.38)

Entrez gene

 126

UniProt

 P00326 (UniProt - Evidence at protein level)

neXtProt

 NX_P00326

Antibodypedia

 ADH1C antibodies

PROTEIN BROWSER
ADH1C-001
ADH1C-002
ADH1C-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADH1C-001
ENSP00000426083
ENST00000515683
P00326 [Direct mapping]
Alcohol dehydrogenase 1C
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0005829 [cytosol]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 375 aa
39.9 kDa 		No 0
ADH1C-002
ENSP00000478545
ENST00000511397
A0A087WUC4 [Direct mapping]
Alcohol dehydrogenase 1C
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 170 aa
17.5 kDa 		No 0
ADH1C-004
ENSP00000478439
ENST00000510055
A0A087WU81 [Direct mapping]
Alcohol dehydrogenase 1C
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 192 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.