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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Specificity

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Cancer

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Tissue

Detectable

Cell line

Detectable

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Detectable

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Antibodies

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ADH1C
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ADH1C

Gene description

Alcohol dehydrogenase 1C (class I), gamma polypeptide

Protein class

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (duodenum, liver, stomach)
GTEx:Group enriched (colon, liver, small intestine, stomach)
FANTOM5:Tissue enhanced (colon, liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in glandular cells of gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 2 antibodies.
HPA047814 , HPA060902
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (duodenum, liver, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, liver, small intestine, stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, liver, small intestine)

GENE INFORMATION

Gene name

ADH1C (HGNC Symbol)

Synonyms

ADH3

Description

Alcohol dehydrogenase 1C (class I), gamma polypeptide (HGNC Symbol)

Entrez gene summary

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q23

Chromosome location (bp)

99336492 - 99353027

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000248144 (version 83.38)

Entrez gene

126

UniProt

P00326 (UniProt - Evidence at protein level)

neXtProt

NX_P00326

Antibodypedia

ADH1C antibodies

PROTEIN BROWSER

ADH1C-001
ADH1C-002
ADH1C-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADH1C-001
ENSP00000426083
ENST00000515683
P00326 [Direct mapping]
Alcohol dehydrogenase 1C
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0005829 [cytosol]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
375 aa
39.9 kDa
No 0
ADH1C-002
ENSP00000478545
ENST00000511397
A0A087WUC4 [Direct mapping]
Alcohol dehydrogenase 1C
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
170 aa
17.5 kDa
No 0
ADH1C-004
ENSP00000478439
ENST00000510055
A0A087WU81 [Direct mapping]
Alcohol dehydrogenase 1C
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
192 aa
19.8 kDa
No 0

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The Human Protein Atlas project is funded
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