Expression of LSM14A in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LSM14A

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LSM14A
Gene description	LSM14A mRNA processing body assembly factor
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (THP-1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA017961
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017961

GENE INFORMATION
Gene name	LSM14A (HGNC Symbol)
Synonyms	C19orf13, DKFZP434D1335, FAM61A, RAP55, RAP55A
Description	LSM14A mRNA processing body assembly factor (HGNC Symbol)
Entrez gene summary	Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	q13.11
Chromosome location (bp)	34172504 - 34229515
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000257103 (version 83.38)
Entrez gene	26065
UniProt	Q8ND56 (UniProt - Evidence at protein level)
neXtProt	NX_Q8ND56
Antibodypedia	LSM14A antibodies

PROTEIN BROWSER

LSM14A-001	LSM14A-002	LSM14A-003	LSM14A-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSM14A-001 ENSP00000446271 ENST00000544216	Q8ND56 [Direct mapping] Protein LSM14 homolog A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000932 [cytoplasmic mRNA processing body] GO:0003690 [double-stranded DNA binding] GO:0003725 [double-stranded RNA binding] GO:0003727 [single-stranded RNA binding] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0007275 [multicellular organismal development] GO:0010494 [cytoplasmic stress granule] GO:0033962 [cytoplasmic mRNA processing body assembly] GO:0039529 [RIG-I signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0051607 [defense response to virus] GO:0060340 [positive regulation of type I interferon-mediated signaling pathway] Show all	463 aa 50.6 kDa	No	0
LSM14A-002 ENSP00000446451 ENST00000540746	Q8ND56 [Direct mapping] Protein LSM14 homolog A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000932 [cytoplasmic mRNA processing body] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0007275 [multicellular organismal development] GO:0010494 [cytoplasmic stress granule] GO:0033962 [cytoplasmic mRNA processing body assembly] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] Show all	422 aa 46.4 kDa	No	0
LSM14A-003 ENSP00000413964 ENST00000433627	Q8ND56 [Direct mapping] Protein LSM14 homolog A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000932 [cytoplasmic mRNA processing body] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0007275 [multicellular organismal development] GO:0010494 [cytoplasmic stress granule] GO:0033962 [cytoplasmic mRNA processing body assembly] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] Show all	463 aa 50.5 kDa	No	0
LSM14A-004 ENSP00000466725 ENST00000586157	K7EMZ9 [Direct mapping] Protein LSM14 homolog A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		314 aa 34.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.