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LSM14A

GENERAL INFORMATION

Gene name

 LSM14A

Gene description

 LSM14A mRNA processing body assembly factor

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA017961
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LSM14A (HGNC Symbol)

Synonyms

 C19orf13, DKFZP434D1335, FAM61A, RAP55, RAP55A

Description

 LSM14A mRNA processing body assembly factor (HGNC Symbol)

Entrez gene summary

 Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

Chromosome

 19

Cytoband

 q13.11

Chromosome location (bp)

 34172504 - 34229515

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000257103 (version 83.38)

Entrez gene

 26065

UniProt

 Q8ND56 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8ND56

Antibodypedia

 LSM14A antibodies

PROTEIN BROWSER
LSM14A-001
LSM14A-002
LSM14A-003
LSM14A-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LSM14A-001
ENSP00000446271
ENST00000544216
Q8ND56 [Direct mapping]
Protein LSM14 homolog A
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003690 [double-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005737 [cytoplasm]
GO:0006417 [regulation of translation]
GO:0007275 [multicellular organismal development]
GO:0010494 [cytoplasmic stress granule]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0039529 [RIG-I signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0051607 [defense response to virus]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
Show all
 463 aa
50.6 kDa 		No 0
LSM14A-002
ENSP00000446451
ENST00000540746
Q8ND56 [Direct mapping]
Protein LSM14 homolog A
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005737 [cytoplasm]
GO:0006417 [regulation of translation]
GO:0007275 [multicellular organismal development]
GO:0010494 [cytoplasmic stress granule]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
Show all
 422 aa
46.4 kDa 		No 0
LSM14A-003
ENSP00000413964
ENST00000433627
Q8ND56 [Direct mapping]
Protein LSM14 homolog A
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005737 [cytoplasm]
GO:0006417 [regulation of translation]
GO:0007275 [multicellular organismal development]
GO:0010494 [cytoplasmic stress granule]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
Show all
 463 aa
50.5 kDa 		No 0
LSM14A-004
ENSP00000466725
ENST00000586157
K7EMZ9 [Direct mapping]
Protein LSM14 homolog A
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 314 aa
34.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.