Expression of CLEC5A in cancer - Summary - The Human Protein Atlas

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CLEC5A

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CLEC5A
Gene description	C-type lectin domain family 5, member A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (HL-60, U-937)
HPA (normal tissue):	Tissue enhanced (appendix, bone marrow)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable).
Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CLEC5A (HGNC Symbol)
Synonyms	CLECSF5, MDL-1
Description	C-type lectin domain family 5, member A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	141927357 - 141947007
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000258227 (version 83.38)
Entrez gene	23601
UniProt	Q9NY25 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NY25
Antibodypedia	CLEC5A antibodies

PROTEIN BROWSER

CLEC5A-001	CLEC5A-003	CLEC5A-004	CLEC5A-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC5A-001 ENSP00000449999 ENST00000546910	Q9NY25 [Direct mapping] C-type lectin domain family 5 member A A4D1U7 [Target identity:100%; Query identity:100%] C-type (Calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5; C-type lectin domain family 5, member A, isoform CRA_b; cDNA FLJ78045, highly similar to Homo sapiens C-type lectin domain family 5, member A (CLEC5A), mRNA; cDNA, FLJ94296, Homo sapiens C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5 (CLECSF5), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001618 [virus receptor activity] GO:0002076 [osteoblast development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0030099 [myeloid cell differentiation] GO:0030246 [carbohydrate binding] GO:0033033 [negative regulation of myeloid cell apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0045087 [innate immune response] GO:0046718 [viral entry into host cell] GO:0050715 [positive regulation of cytokine secretion] Show all	188 aa 21.5 kDa	No	1
CLEC5A-003 ENSP00000446890 ENST00000551012	Q14DL9 [Direct mapping] C-type lectin domain family 5 member A; CLEC5A protein; cDNA FLJ51846, highly similar to C-type lectin domain family 5 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	165 aa 19.1 kDa	No	1
CLEC5A-004 ENSP00000395258 ENST00000439991	C9JCE4 [Direct mapping] C-type lectin domain family 5 member A Show all	Predicted intracellular proteins Show all		84 aa 9.7 kDa	No	0
CLEC5A-006 ENSP00000414897 ENST00000438351	C9JPR7 [Direct mapping] C-type lectin domain family 5 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	155 aa 18 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.