Tissue expression of CLEC5A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CLEC5A
Gene description	C-type lectin domain family 5, member A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (appendix, bone marrow)
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION
Gene name	CLEC5A (HGNC Symbol)
Synonyms	CLECSF5, MDL-1
Description	C-type lectin domain family 5, member A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	141927357 - 141947007
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000258227 (version 83.38)
Entrez gene	23601
UniProt	Q9NY25 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NY25
Antibodypedia	CLEC5A antibodies

PROTEIN BROWSER

CLEC5A-001	CLEC5A-003	CLEC5A-004	CLEC5A-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC5A-001 ENSP00000449999 ENST00000546910	Q9NY25 [Direct mapping] C-type lectin domain family 5 member A A4D1U7 [Target identity:100%; Query identity:100%] C-type (Calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5; C-type lectin domain family 5, member A, isoform CRA_b; cDNA FLJ78045, highly similar to Homo sapiens C-type lectin domain family 5, member A (CLEC5A), mRNA; cDNA, FLJ94296, Homo sapiens C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5 (CLECSF5), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001618 [virus receptor activity] GO:0002076 [osteoblast development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0030099 [myeloid cell differentiation] GO:0030246 [carbohydrate binding] GO:0033033 [negative regulation of myeloid cell apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0045087 [innate immune response] GO:0046718 [viral entry into host cell] GO:0050715 [positive regulation of cytokine secretion] Show all	188 aa 21.5 kDa	No	1
CLEC5A-003 ENSP00000446890 ENST00000551012	Q14DL9 [Direct mapping] C-type lectin domain family 5 member A; CLEC5A protein; cDNA FLJ51846, highly similar to C-type lectin domain family 5 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	165 aa 19.1 kDa	No	1
CLEC5A-004 ENSP00000395258 ENST00000439991	C9JCE4 [Direct mapping] C-type lectin domain family 5 member A Show all	Predicted intracellular proteins Show all		84 aa 9.7 kDa	No	0
CLEC5A-006 ENSP00000414897 ENST00000438351	C9JPR7 [Direct mapping] C-type lectin domain family 5 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	155 aa 18 kDa	No	1