Expression of C17orf49 in cancer - Summary - The Human Protein Atlas

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C17orf49

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C17orf49
Gene description	Chromosome 17 open reading frame 49
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA022961 , HPA024457
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022961	HPA024457

GENE INFORMATION
Gene name	C17orf49 (HGNC Symbol)
Synonyms	BAP18, HEPIS, MGC49942
Description	Chromosome 17 open reading frame 49 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7014495 - 7017525
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000258315 (version 83.38)
Entrez gene	124944
UniProt	Q8IXM2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IXM2
Antibodypedia	C17orf49 antibodies

PROTEIN BROWSER

C17orf49-001	C17orf49-003	C17orf49-004	C17orf49-005	C17orf49-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C17orf49-001 ENSP00000411851 ENST00000439424	Q8IXM2 [Direct mapping] Chromatin complexes subunit BAP18 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0016568 [chromatin modification] GO:0016589 [NURF complex] GO:0071339 [MLL1 complex] Show all	172 aa 17.9 kDa	No	0
C17orf49-003 ENSP00000447646 ENST00000546760	F8W038 [Direct mapping] Chromatin complexes subunit BAP18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	157 aa 16.3 kDa	No	0
C17orf49-004 ENSP00000448746 ENST00000552402	Q8IXM2 [Direct mapping] Chromatin complexes subunit BAP18 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0016568 [chromatin modification] GO:0016589 [NURF complex] GO:0071339 [MLL1 complex] Show all	138 aa 14 kDa	No	0
C17orf49-005 ENSP00000447063 ENST00000552775	F8W1H0 [Direct mapping] Chromatin complexes subunit BAP18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	166 aa 17.4 kDa	No	0
C17orf49-006 ENSP00000448598 ENST00000546495	Q8IXM2 [Direct mapping] Chromatin complexes subunit BAP18 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0016568 [chromatin modification] GO:0016589 [NURF complex] GO:0071339 [MLL1 complex] Show all	192 aa 20 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.