Cell atlas - PAK6 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PAK6
Gene description	P21 protein (Cdc42/Rac)-activated kinase 6
Protein class	Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli (fibrillar center). In addition localized to the cell junctions. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli fibrillar center (approved)
Additional location	In addition localized to the Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA031124
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli (fibrillar center). In addition localized to the cell junctions. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleus (approved), Nucleoli fibrillar center (approved)

Additional location

Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA031124	A-431	Nucleus
HPA031124	A-431	Cell Junctions
HPA031124	CACO-2	Nucleus
		Nucleoli fibrillar center
		Cell Junctions
HPA031124	U-2 OS	Nucleus
HPA031124	U-2 OS	Nucleoli fibrillar center

GENE INFORMATION
Gene name	PAK6
Synonyms
Description	P21 protein (Cdc42/Rac)-activated kinase 6 (EntrezGene)
Entrez gene summary
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40217428 - 40276396
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000259288 (version 83.38)
Entrez gene	56924
UniProt
neXtProt
Antibodypedia	PAK6 antibodies

PROTEIN BROWSER

PAK6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAK6-002 ENSP00000406873 ENST00000441369	A0A024R9Q4 [Target identity:100%; Query identity:100%] Non-specific serine/threonine protein kinase Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	681 aa 74.9 kDa	No	0