Expression of PAK6 in cancer - Summary - The Human Protein Atlas

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PAK6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PAK6
Gene description	P21 protein (Cdc42/Rac)-activated kinase 6
Protein class	Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA031124
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031124

GENE INFORMATION
Gene name	PAK6
Synonyms
Description	P21 protein (Cdc42/Rac)-activated kinase 6 (EntrezGene)
Entrez gene summary
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40217428 - 40276396
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000259288 (version 83.38)
Entrez gene	56924
UniProt
neXtProt
Antibodypedia	PAK6 antibodies

PROTEIN BROWSER

PAK6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAK6-002 ENSP00000406873 ENST00000441369	A0A024R9Q4 [Target identity:100%; Query identity:100%] Non-specific serine/threonine protein kinase Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	681 aa 74.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.