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HOXB7

GENERAL INFORMATION

Gene name

 HOXB7

Gene description

 Homeobox B7

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (EFO-21)
HPA (normal tissue):Tissue enhanced (epididymis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA049940
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049940

GENE INFORMATION

Gene name

 HOXB7 (HGNC Symbol)

Synonyms

 HOX2, HOX2C

Description

 Homeobox B7 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48607227 - 48633572

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000260027 (version 83.38)

Entrez gene

 3217

UniProt

 P09629 (UniProt - Evidence at protein level)

neXtProt

 NX_P09629

Antibodypedia

 HOXB7 antibodies

PROTEIN BROWSER
HOXB7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXB7-001
ENSP00000239165
ENST00000239165
P09629 [Direct mapping]
Homeobox protein Hox-B7
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0009952 [anterior/posterior pattern specification]
GO:0030099 [myeloid cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
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 217 aa
24 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.