Expression of MRC1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MRC1
Gene description	Mannose receptor, C type 1
Protein class	CD markers Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (MOLT-4, TIME)
HPA (normal tissue):	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in macrophages in several tissues including lung macrophages, Kupffer cells in liver and placental Hofbauer cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 3 antibodies. HPA004114 , HPA045134 , CAB068203
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA004114	HPA045134	CAB068203

GENE INFORMATION
Gene name	MRC1 (HGNC Symbol)
Synonyms	bA541I19.1, CD206, CLEC13D, CLEC13DL, MRC1L1
Description	Mannose receptor, C type 1 (HGNC Symbol)
Entrez gene summary	The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Chromosome	10
Cytoband	p12.33
Chromosome location (bp)	17809344 - 17911170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000260314 (version 83.38)
Entrez gene	4360
UniProt	P22897 (UniProt - Evidence at protein level)
neXtProt	NX_P22897
Antibodypedia	MRC1 antibodies

PROTEIN BROWSER

MRC1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRC1-001 ENSP00000455897 ENST00000569591	P22897 [Direct mapping] Macrophage mannose receptor 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0001618 [virus receptor activity] GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005537 [mannose binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0046718 [viral entry into host cell] GO:0071222 [cellular response to lipopolysaccharide] GO:0071346 [cellular response to interferon-gamma] GO:0071353 [cellular response to interleukin-4] Show all	1456 aa 166 kDa	Yes	1