Cell atlas - KCNJ18 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNJ18
Gene description	Potassium channel, inwardly rectifying subfamily J, member 18
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the cytosol & nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (uncertain)
Additional location	In addition localized to the Nucleoplasm (uncertain), Cytosol (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA027021
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the cytosol & nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Golgi apparatus (uncertain)

Additional location

Nucleoplasm (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA027021	PC-3	Nucleoplasm	Intensity
		Golgi apparatus
		Cytosol
HPA027021	U-2 OS	Golgi apparatus
HPA027021	U-251 MG	Nucleoplasm
		Golgi apparatus
		Cytosol

GENE INFORMATION
Gene name	KCNJ18 (HGNC Symbol)
Synonyms	KIR2.6, TTPP2
Description	Potassium channel, inwardly rectifying subfamily J, member 18 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic periodic paralysis. [provided by RefSeq, Jan 2013]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	21692523 - 21704612
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000260458 (version 83.38)
Entrez gene	100134444
UniProt	B7U540 (UniProt - Evidence at protein level)
neXtProt	NX_B7U540
Antibodypedia	KCNJ18 antibodies

PROTEIN BROWSER

KCNJ18-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ18-001 ENSP00000457807 ENST00000567955	B7U540 [Target identity:100%; Query identity:100%] Inward rectifier potassium channel 18 A0A075B742 [Direct mapping] Inward rectifier potassium channel 18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	433 aa 48.9 kDa	No	3