Expression of KCNJ18 in cancer - Summary - The Human Protein Atlas

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KCNJ18

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCNJ18
Gene description	Potassium channel, inwardly rectifying subfamily J, member 18
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (cervical cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (skin, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA027021
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (cervical cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027021

GENE INFORMATION
Gene name	KCNJ18 (HGNC Symbol)
Synonyms	KIR2.6, TTPP2
Description	Potassium channel, inwardly rectifying subfamily J, member 18 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic periodic paralysis. [provided by RefSeq, Jan 2013]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	21692523 - 21704612
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000260458 (version 83.38)
Entrez gene	100134444
UniProt	B7U540 (UniProt - Evidence at protein level)
neXtProt	NX_B7U540
Antibodypedia	KCNJ18 antibodies

PROTEIN BROWSER

KCNJ18-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ18-001 ENSP00000457807 ENST00000567955	B7U540 [Target identity:100%; Query identity:100%] Inward rectifier potassium channel 18 A0A075B742 [Direct mapping] Inward rectifier potassium channel 18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	433 aa 48.9 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.