Expression of EPPK1 in cancer - Summary

GENERAL INFORMATION
Gene name	EPPK1
Gene description	Epiplakin 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, EFO-21, HaCaT, HeLa, MCF7)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in epithelial and glandular cells in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA069333
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and pancreatic cancer (unfavourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA069333

GENE INFORMATION
Gene name	EPPK1 (HGNC Symbol)
Synonyms	EPIPL1
Description	Epiplakin 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the plakin family of proteins, which play a role in the organization of cytoskeletal architecture. This family member is composed of several highly homologous plakin repeats. It may function to maintain the integrity of keratin intermediate filament networks in epithelial cells. Studies of the orthologous mouse protein suggest that it accelerates keratinocyte migration during wound healing. [provided by RefSeq, Oct 2013]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	143857324 - 143878464
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000261150 (version 83.38)
Entrez gene	83481
UniProt
neXtProt
Antibodypedia	EPPK1 antibodies

PROTEIN BROWSER

EPPK1-001	EPPK1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPPK1-001 ENSP00000484472 ENST00000615648	A0A087X1U6 [Direct mapping] Epiplakin Show all	Predicted intracellular proteins Show all	GO:0005856 [cytoskeleton] Show all	5088 aa 555.7 kDa	No	0
EPPK1-201 ENSP00000456124 ENST00000568225	A0A075B730 [Direct mapping] Epiplakin Show all	Predicted intracellular proteins Show all	GO:0005856 [cytoskeleton] Show all	5063 aa 553.1 kDa	No	0