Fields »
ABOUT
HELP
BLOG
BOP1

GENERAL INFORMATION

Gene name

 BOP1

Gene description

 Block of proliferation 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression mainly in glandular cells, seminiferous ducts of testis and CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA047869
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA047869

GENE INFORMATION

Gene name

 BOP1 (HGNC Symbol)

Synonyms

 KIAA0124

Description

 Block of proliferation 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 144262102 - 144291370

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000261236 (version 83.38)

Entrez gene

 23246

UniProt

 Q14137 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14137

Antibodypedia

 BOP1 antibodies

PROTEIN BROWSER
BOP1-001
BOP1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BOP1-001
ENSP00000455106
ENST00000569669
Q14137 [Direct mapping]
Ribosome biogenesis protein BOP1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000448 [cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000463 [maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0008283 [cell proliferation]
GO:0030529 [ribonucleoprotein complex]
GO:0030687 [preribosome, large subunit precursor]
GO:0042254 [ribosome biogenesis]
GO:0042273 [ribosomal large subunit biogenesis]
GO:0043021 [ribonucleoprotein complex binding]
GO:0044822 [poly(A) RNA binding]
GO:0051726 [regulation of cell cycle]
GO:0070545 [PeBoW complex]
Show all
 746 aa
83.6 kDa 		No 0
BOP1-003
ENSP00000456082
ENST00000569403
A0A075B729 [Direct mapping]
Ribosome biogenesis protein BOP1
Show all
Predicted intracellular proteins
Show all
GO:0006364 [rRNA processing]
Show all
 217 aa
24.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.