Expression of PECAM1 in cancer - Summary - The Human Protein Atlas

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PECAM1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PECAM1
Gene description	Platelet/endothelial cell adhesion molecule 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HUVEC TERT2, TIME)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in endothelial cells and smooth muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA004690
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004690

GENE INFORMATION
Gene name	PECAM1 (HGNC Symbol)
Synonyms	CD31
Description	Platelet/endothelial cell adhesion molecule 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	64319415 - 64413776
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000261371 (version 83.38)
Entrez gene	5175
UniProt
neXtProt
Antibodypedia	PECAM1 antibodies

PROTEIN BROWSER

PECAM1-001	PECAM1-002	PECAM1-003	PECAM1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PECAM1-001 ENSP00000457421 ENST00000563924	A0A075B738 [Direct mapping] Platelet endothelial cell adhesion molecule Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0007266 [Rho protein signal transduction] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030334 [regulation of cell migration] GO:0030485 [smooth muscle contractile fiber] GO:0042060 [wound healing] GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein] GO:0045121 [membrane raft] GO:0071944 [cell periphery] Show all	738 aa 82.5 kDa	Yes	1
PECAM1-002 ENSP00000457218 ENST00000569967	A0A075B737 [Direct mapping] Platelet endothelial cell adhesion molecule Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	135 aa 15.3 kDa	Yes	0
PECAM1-003 ENSP00000455663 ENST00000564866	A0A075B727 [Direct mapping] Platelet endothelial cell adhesion molecule Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	230 aa 26.2 kDa	Yes	0
PECAM1-004 ENSP00000455931 ENST00000563523	A0A075B728 [Direct mapping] Platelet endothelial cell adhesion molecule Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	184 aa 20.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.