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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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OTUD7B
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

OTUD7B

Gene description

OTU deubiquitinase 7B

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA027045
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PROGNOSTIC SUMMARY

Prognostic marker in melanoma (favourable) and endometrial cancer (favourable).
Melanoma p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA027045

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate cytoplasmic and/or nuclear immunoreactivity. Strong staining was observed in a few cases of melanomas, breast, endometrial, liver and colorectal cancers.

GENE INFORMATION

Gene name

OTUD7B (HGNC Symbol)

Synonyms

CEZANNE, ZA20D1

Description

OTU deubiquitinase 7B (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

q21.2

Chromosome location (bp)

149937812 - 150010676

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000264522 (version 83.38)

Entrez gene

56957

UniProt

Q6GQQ9 (UniProt - Evidence at protein level)

neXtProt

NX_Q6GQQ9

Antibodypedia

OTUD7B antibodies

PROTEIN BROWSER

OTUD7B-001
OTUD7B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OTUD7B-001
ENSP00000462729
ENST00000581312
Q6GQQ9 [Direct mapping]
OTU domain-containing protein 7B
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002385 [mucosal immune response]
GO:0003677 [DNA binding]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008234 [cysteine-type peptidase activity]
GO:0008270 [zinc ion binding]
GO:0016579 [protein deubiquitination]
GO:0032717 [negative regulation of interleukin-8 production]
GO:0035871 [protein K11-linked deubiquitination]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045088 [regulation of innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
GO:0071947 [protein deubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:1900181 [negative regulation of protein localization to nucleus]
GO:1990380 [Lys48-specific deubiquitinase activity]
Show all
843 aa
92.5 kDa
No 0
OTUD7B-003
ENSP00000408231
ENST00000417191
Q5SZ59 [Direct mapping]
OTU domain containing 7B; OTU domain-containing protein 7B
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Predicted intracellular proteins
Show all
427 aa
47.6 kDa
No 0

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