Expression of RBP3 in cancer - Summary - The Human Protein Atlas

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RBP3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RBP3
Gene description	Retinol binding protein 3, interstitial
Protein class	Disease related genes Enzymes Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in photoreceptor cells.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 2 antibodies. HPA041301 , HPA044239
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041301	HPA044239

GENE INFORMATION
Gene name	RBP3 (HGNC Symbol)
Synonyms	D10S64, D10S65, D10S66, RP66
Description	Retinol binding protein 3, interstitial (HGNC Symbol)
Entrez gene summary	Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	47348371 - 47357875
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000265203 (version 83.38)
Entrez gene	5949
UniProt	P10745 (UniProt - Evidence at protein level)
neXtProt	NX_P10745
Antibodypedia	RBP3 antibodies

PROTEIN BROWSER

RBP3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBP3-001 ENSP00000463151 ENST00000584701	P10745 [Direct mapping] Retinol-binding protein 3 Show all	Enzymes Peptidases Serine-type peptidases THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0005501 [retinoid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006629 [lipid metabolic process] GO:0006810 [transport] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008236 [serine-type peptidase activity] GO:0016918 [retinal binding] GO:0019841 [retinol binding] GO:0033165 [interphotoreceptor matrix] GO:1903561 [extracellular vesicle] Show all	1247 aa 135.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.