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ZNF488

GENERAL INFORMATION

Gene name

 ZNF488

Gene description

 Zinc finger protein 488

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HaCaT, HDLM-2, RT4)
HPA (normal tissue):Group enriched (cerebral cortex, duodenum, placenta, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA035957 , HPA044867
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA035957
HPA044867

GENE INFORMATION

Gene name

 ZNF488 (HGNC Symbol)

Synonyms

 FLJ32104

Description

 Zinc finger protein 488 (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q11.22

Chromosome location (bp)

 47365496 - 47384273

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000265763 (version 83.38)

Entrez gene

 118738

UniProt

 Q96MN9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96MN9

Antibodypedia

 ZNF488 antibodies

PROTEIN BROWSER
ZNF488-001
ZNF488-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNF488-001
ENSP00000462269
ENST00000585316
Q96MN9 [Direct mapping]
Zinc finger protein 488
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0014003 [oligodendrocyte development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
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 340 aa
37 kDa 		Yes 0
ZNF488-201
ENSP00000468133
ENST00000591025
Q96MN9 [Direct mapping]
Zinc finger protein 488
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Predicted intracellular proteins
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0014003 [oligodendrocyte development]
GO:0046872 [metal ion binding]
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 233 aa
25.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.