Expression of AARSD1 in cancer - Summary

GENERAL INFORMATION
Gene name	AARSD1
Gene description	Alanyl-tRNA synthetase domain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in several cell types. Most abundant in cells in seminiferus ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA021408 , HPA022869 , HPA023714
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA021408	HPA022869	HPA023714

GENE INFORMATION
Gene name	AARSD1 (HGNC Symbol)
Synonyms	MGC2744
Description	Alanyl-tRNA synthetase domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	42950526 - 42964498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000266967 (version 83.38)
Entrez gene	80755
UniProt	Q9BTE6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTE6
Antibodypedia	AARSD1 antibodies

PROTEIN BROWSER

AARSD1-001	AARSD1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AARSD1-001 ENSP00000400870 ENST00000427569	Q9BTE6 [Direct mapping] Alanyl-tRNA editing protein Aarsd1 Show all	Predicted intracellular proteins Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0002161 [aminoacyl-tRNA editing activity] GO:0002196 [Ser-tRNA(Ala) hydrolase activity] GO:0003674 [molecular_function] GO:0003676 [nucleic acid binding] GO:0004813 [alanine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006419 [alanyl-tRNA aminoacylation] GO:0006450 [regulation of translational fidelity] GO:0008150 [biological_process] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] GO:0046872 [metal ion binding] Show all	412 aa 45.5 kDa	No	0
AARSD1-013 ENSP00000400735 ENST00000430739	L7N2F4 [Direct mapping] Alanyl-tRNA-editing protein Aarsd1 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0005524 [ATP binding] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] Show all	140 aa 15.5 kDa	No	0