Expression of APOC4 in cancer - Summary - The Human Protein Atlas

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APOC4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	APOC4
Gene description	Apolipoprotein C-IV
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (HEL, SK-MEL-30)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Positivity in plasma.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA062671
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA062671

GENE INFORMATION
Gene name	APOC4
Synonyms
Description	Apolipoprotein C-IV (HGNC Symbol)
Entrez gene summary	This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	44942238 - 44945496
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000267467 (version 83.38)
Entrez gene	346
UniProt	P55056 (UniProt - Evidence at protein level)
neXtProt	NX_P55056
Antibodypedia	APOC4 antibodies

PROTEIN BROWSER

APOC4-001	APOC4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOC4-001 ENSP00000468236 ENST00000592954	P55056 [Direct mapping] Apolipoprotein C-IV Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0010890 [positive regulation of sequestering of triglyceride] GO:0034361 [very-low-density lipoprotein particle] GO:0034364 [high-density lipoprotein particle] GO:0070328 [triglyceride homeostasis] Show all	127 aa 14.6 kDa	Yes	0
APOC4-002 ENSP00000466444 ENST00000591600	K7EMC3 [Direct mapping] Apolipoprotein C-IV Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		73 aa 8.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.