Fields »
ABOUT
HELP
BLOG
S1PR2

GENERAL INFORMATION

Gene name

 S1PR2

Gene description

 Sphingosine-1-phosphate receptor 2

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (placenta)
GTEx:Tissue enhanced (testis)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in erythrocytes and intestinal microvilli.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA014307
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 S1PR2 (HGNC Symbol)

Synonyms

 AGR16, EDG5, Gpcr13, H218

Description

 Sphingosine-1-phosphate receptor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10221435 - 10231272

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000267534 (version 83.38)

Entrez gene

 9294

UniProt

 O95136 (UniProt - Evidence at protein level)

neXtProt

 NX_O95136

Antibodypedia

 S1PR2 antibodies

PROTEIN BROWSER
S1PR2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
S1PR2-001
ENSP00000466933
ENST00000590320
O95136 [Direct mapping]
Sphingosine 1-phosphate receptor 2
A0A024R7B2 [Target identity:100%; Query identity:100%]
Endothelial differentiation, sphingolipid G-protein-coupled receptor, 5, isoform CRA_a
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Lysolipids receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001664 [G-protein coupled receptor binding]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0016021 [integral component of membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0038036 [sphingosine-1-phosphate receptor activity]
GO:0046847 [filopodium assembly]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:1903142 [positive regulation of establishment of endothelial barrier]
Show all
 353 aa
38.9 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.