Expression of NBPF12 in cancer - Summary - The Human Protein Atlas

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NBPF12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NBPF12
Gene description	Neuroblastoma breakpoint family, member 12
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 7 antibodies. HPA038748 , HPA042595 , HPA043105 , HPA043692 , HPA044023 , HPA046971 , HPA058050
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and urothelial cancer (favourable).
Pancreatic cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038748	HPA042595	HPA043105	HPA043692	HPA044023	HPA046971	HPA058050

GENE INFORMATION
Gene name	NBPF12 (HGNC Symbol)
Synonyms	COAS1, KIAA1245
Description	Neuroblastoma breakpoint family, member 12 (HGNC Symbol)
Entrez gene summary	This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, May 2013]
Chromosome	1
Cytoband	q21.1
Chromosome location (bp)	146938744 - 146996202
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000268043 (version 83.38)
Entrez gene	149013
UniProt
neXtProt
Antibodypedia	NBPF12 antibodies

PROTEIN BROWSER

NBPF12-001	NBPF12-201	NBPF12-202	NBPF12-203	NBPF12-204	NBPF12-205	NBPF12-206	NBPF12-207

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NBPF12-001 ENSP00000478609 ENST00000617931	A0A087WUF1 [Direct mapping] Neuroblastoma breakpoint family member 12 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		1457 aa 167.7 kDa	No	0
NBPF12-201 ENSP00000391949 ENST00000439206	H7BZX4 [Direct mapping] Neuroblastoma breakpoint family member 12 Show all	Predicted intracellular proteins Show all		577 aa 66.8 kDa	No	0
NBPF12-202 ENSP00000464426 ENST00000579935	A0A075B764 [Direct mapping] Neuroblastoma breakpoint family member 12 Show all	Predicted intracellular proteins Show all		1111 aa 128 kDa	No	0
NBPF12-203 ENSP00000481469 ENST00000611443	A0A087WY24 [Direct mapping] Neuroblastoma breakpoint family member 12 Show all	Predicted intracellular proteins Show all		1213 aa 139.5 kDa	No	0
NBPF12-204 ENSP00000480046 ENST00000613714	A0A087WW93 [Direct mapping] Neuroblastoma breakpoint family member 12 Show all	Predicted intracellular proteins Show all		867 aa 99.8 kDa	No	0
NBPF12-205 ENSP00000478967 ENST00000617614	A0A087WUW2 [Direct mapping] Neuroblastoma breakpoint family member 12 Show all	Predicted intracellular proteins Show all		865 aa 99.5 kDa	No	0
NBPF12-206 ENSP00000484391 ENST00000617844	A0A087WUF1 [Direct mapping] Neuroblastoma breakpoint family member 12 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		1457 aa 167.7 kDa	No	0
NBPF12-207 ENSP00000483451 ENST00000617864	A0A087X0J8 [Direct mapping] Neuroblastoma breakpoint family member 12 Show all	Predicted intracellular proteins Show all		299 aa 34 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.