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SLC6A14

GENERAL INFORMATION

Gene name

 SLC6A14

Gene description

 Solute carrier family 6 (amino acid transporter), member 14

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HeLa, Hep G2)
HPA (normal tissue):Tissue enhanced (cervix, uterine, lung)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Mainly cytoplasmic expresion in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA003193
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA003193

GENE INFORMATION

Gene name

 SLC6A14

Synonyms

Description

 Solute carrier family 6 (amino acid transporter), member 14 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q23

Chromosome location (bp)

 116436622 - 116461458

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000268104 (version 83.38)

Entrez gene

 11254

UniProt

 Q9UN76 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UN76

Antibodypedia

 SLC6A14 antibodies

PROTEIN BROWSER
SLC6A14-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC6A14-001
ENSP00000470801
ENST00000598581
Q9UN76 [Direct mapping]
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
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GO:0003333 [amino acid transmembrane transport]
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006520 [cellular amino acid metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006836 [neurotransmitter transport]
GO:0006865 [amino acid transport]
GO:0009636 [response to toxic substance]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0031526 [brush border membrane]
GO:0031982 [vesicle]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 642 aa
72.2 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.