Tissue expression of SLC6A14 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC6A14
Gene description	Solute carrier family 6 (amino acid transporter), member 14
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cervix, uterine, lung)
FANTOM5:	Tissue enhanced (lung, pituitary gland, salivary gland)

Protein evidence

Evidence at transcript level

Protein expression

Mainly cytoplasmic expresion in most tissues.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA003193
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cervix, uterine, lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, pituitary gland, salivary gland)

GENE INFORMATION
Gene name	SLC6A14
Synonyms
Description	Solute carrier family 6 (amino acid transporter), member 14 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q23
Chromosome location (bp)	116436622 - 116461458
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000268104 (version 83.38)
Entrez gene	11254
UniProt	Q9UN76 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UN76
Antibodypedia	SLC6A14 antibodies

PROTEIN BROWSER

SLC6A14-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A14-001 ENSP00000470801 ENST00000598581	Q9UN76 [Direct mapping] Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0003333 [amino acid transmembrane transport] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006836 [neurotransmitter transport] GO:0006865 [amino acid transport] GO:0009636 [response to toxic substance] GO:0015171 [amino acid transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0031526 [brush border membrane] GO:0031982 [vesicle] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	642 aa 72.2 kDa	No	>9