Expression of CALR3 in cancer - Summary - The Human Protein Atlas

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CALR3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CALR3
Gene description	Calreticulin 3
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in cells of seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA043355 , HPA048460 , CAB025749
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043355	HPA048460	CAB025749

GENE INFORMATION
Gene name	CALR3 (HGNC Symbol)
Synonyms	CRT2, CT93, FLJ25355, MGC26577
Description	Calreticulin 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	16479057 - 16496192
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000269058 (version 83.38)
Entrez gene	125972
UniProt	Q96L12 (UniProt - Evidence at protein level)
neXtProt	NX_Q96L12
Antibodypedia	CALR3 antibodies

PROTEIN BROWSER

CALR3-001	CALR3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CALR3-001 ENSP00000269881 ENST00000269881	Q96L12 [Direct mapping] Calreticulin-3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0030246 [carbohydrate binding] GO:0044183 [protein binding involved in protein folding] GO:0051082 [unfolded protein binding] Show all	384 aa 45 kDa	Yes	0
CALR3-002 ENSP00000471533 ENST00000600762	M0R0Y8 [Direct mapping] Calreticulin-3 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	142 aa 16.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.