Expression of NBPF9 in cancer - Summary - The Human Protein Atlas

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NBPF9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NBPF9
Gene description	Neuroblastoma breakpoint family, member 9
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 7 antibodies. HPA038748 , HPA042595 , HPA043105 , HPA043692 , HPA044023 , HPA046971 , HPA058050
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038748	HPA042595	HPA043105	HPA043692	HPA044023	HPA046971	HPA058050

GENE INFORMATION
Gene name	NBPF9 (HGNC Symbol)
Synonyms	AE01
Description	Neuroblastoma breakpoint family, member 9 (HGNC Symbol)
Entrez gene summary	This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Apr 2013]
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	149054027 - 149103561
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000269713 (version 83.38)
Entrez gene	400818
UniProt
neXtProt
Antibodypedia	NBPF9 antibodies

PROTEIN BROWSER

NBPF9-002	NBPF9-007	NBPF9-008	NBPF9-201	NBPF9-202	NBPF9-203	NBPF9-204	NBPF9-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NBPF9-002 ENSP00000477979 ENST00000615421	A0A075B761 [Direct mapping] Neuroblastoma breakpoint family member 9 Show all	Predicted intracellular proteins Show all		1111 aa 127.8 kDa	No	0
NBPF9-007 ENSP00000482587 ENST00000621645	A0A087WZE1 [Direct mapping] Neuroblastoma breakpoint family member 9 Show all	Predicted intracellular proteins Show all		981 aa 113.1 kDa	No	0
NBPF9-008 ENSP00000481471 ENST00000610300	A0A087WY26 [Direct mapping] Neuroblastoma breakpoint family member 9 Show all	Predicted intracellular proteins Show all		942 aa 108.4 kDa	No	0
NBPF9-201 ENSP00000483736 ENST00000483630	A0A087X0Y3 [Direct mapping] Neuroblastoma breakpoint family member 9 Show all	Predicted intracellular proteins Show all		299 aa 34.1 kDa	No	0
NBPF9-202 ENSP00000463665 ENST00000584027	A0A075B761 [Direct mapping] Neuroblastoma breakpoint family member 9 Show all	Predicted intracellular proteins Show all		1111 aa 127.8 kDa	No	0
NBPF9-203 ENSP00000483900 ENST00000613595	A0A087WY26 [Direct mapping] Neuroblastoma breakpoint family member 9 Show all	Predicted intracellular proteins Show all		942 aa 108.4 kDa	No	0
NBPF9-204 ENSP00000482016 ENST00000613969	A0A087WYQ9 [Direct mapping] Neuroblastoma breakpoint family member 9 Show all	Predicted intracellular proteins Show all		942 aa 108.4 kDa	No	0
NBPF9-205 ENSP00000479415 ENST00000621074	A0A087WVG0 [Direct mapping] Neuroblastoma breakpoint family member 9 Show all	Predicted intracellular proteins Show all		867 aa 99.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.