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NUDT3

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GENERAL INFORMATION

Gene name

 NUDT3

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA047027
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA047027 HEK 293 Cytosol
HPA047027 U-2 OS Cytosol
HPA047027 U-251 MG Cytosol

GENE INFORMATION

Gene name

 NUDT3 (HGNC Symbol)

Synonyms

 DIPP

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 3 (HGNC Symbol)

Entrez gene summary

 NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 34279679 - 34392674

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000272325 (version 83.38)

Entrez gene

 11165

UniProt

 O95989 (UniProt - Evidence at protein level)

neXtProt

 NX_O95989

Antibodypedia

 NUDT3 antibodies

PROTEIN BROWSER
NUDT3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT3-001
ENSP00000476119
ENST00000607016
O95989 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005829 [cytosol]
GO:0007267 [cell-cell signaling]
GO:0008486 [diphosphoinositol-polyphosphate diphosphatase activity]
GO:0015961 [diadenosine polyphosphate catabolic process]
GO:0016787 [hydrolase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052840 [inositol diphosphate tetrakisphosphate diphosphatase activity]
GO:0052843 [inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052844 [inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052845 [inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity]
GO:0052846 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity]
GO:0052847 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
GO:0052848 [inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
GO:0070062 [extracellular exosome]
GO:0071544 [diphosphoinositol polyphosphate catabolic process]
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 172 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.