Fields »
ABOUT
HELP
BLOG
NUDT3

GENERAL INFORMATION

Gene name

 NUDT3

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 2 antibodies.
HPA047027 , HPA055953
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047027
HPA055953

GENE INFORMATION

Gene name

 NUDT3 (HGNC Symbol)

Synonyms

 DIPP

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 3 (HGNC Symbol)

Entrez gene summary

 NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 34279679 - 34392674

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000272325 (version 83.38)

Entrez gene

 11165

UniProt

 O95989 (UniProt - Evidence at protein level)

neXtProt

 NX_O95989

Antibodypedia

 NUDT3 antibodies

PROTEIN BROWSER
NUDT3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT3-001
ENSP00000476119
ENST00000607016
O95989 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005829 [cytosol]
GO:0007267 [cell-cell signaling]
GO:0008486 [diphosphoinositol-polyphosphate diphosphatase activity]
GO:0015961 [diadenosine polyphosphate catabolic process]
GO:0016787 [hydrolase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052840 [inositol diphosphate tetrakisphosphate diphosphatase activity]
GO:0052843 [inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052844 [inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052845 [inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity]
GO:0052846 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity]
GO:0052847 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
GO:0052848 [inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
GO:0070062 [extracellular exosome]
GO:0071544 [diphosphoinositol polyphosphate catabolic process]
Show all
 172 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.