Expression of TBC1D3B in cancer - Summary - The Human Protein Atlas

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TBC1D3B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TBC1D3B
Gene description	TBC1 domain family, member 3B
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (CAPAN-2)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic positivity in several different tissue types, including testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 3 antibodies. HPA046969 , HPA047745 , HPA052553
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046969	HPA047745	HPA052553

GENE INFORMATION
Gene name	TBC1D3B (HGNC Symbol)
Synonyms	PRC17, TBC1D3I
Description	TBC1 domain family, member 3B (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are multiple copies of this gene located within a cluster of chemokine genes on chromosome 17q. [provided by RefSeq, Apr 2009]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	36165624 - 36264527
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000274808 (version 83.38)
Entrez gene	414059
UniProt	A6NDS4 (UniProt - Evidence at transcript level)
neXtProt	NX_A6NDS4
Antibodypedia	TBC1D3B antibodies

PROTEIN BROWSER

TBC1D3B-001	TBC1D3B-004	TBC1D3B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBC1D3B-001 ENSP00000478473 ENST00000611257	A6NDS4 [Direct mapping] TBC1 domain family member 3B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005096 [GTPase activator activity] GO:0005886 [plasma membrane] GO:0043547 [positive regulation of GTPase activity] Show all	549 aa 62.3 kDa	No	1
TBC1D3B-004 ENSP00000478440 ENST00000616006	A0A087WU82 [Direct mapping] TBC1 domain family member 3B Show all	Predicted intracellular proteins Show all		49 aa 5.9 kDa	No	0
TBC1D3B-201 ENSP00000484556 ENST00000615673	A6NDS4 [Direct mapping] TBC1 domain family member 3B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005096 [GTPase activator activity] GO:0005886 [plasma membrane] GO:0043547 [positive regulation of GTPase activity] Show all	549 aa 62.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.