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TBC1D3B

GENERAL INFORMATION

Gene name

 TBC1D3B

Gene description

 TBC1 domain family, member 3B

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic positivity in several different tissue types, including testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 3 antibodies.
HPA046969 , HPA047745 , HPA052553
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)

GENE INFORMATION

Gene name

 TBC1D3B (HGNC Symbol)

Synonyms

 PRC17, TBC1D3I

Description

 TBC1 domain family, member 3B (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are multiple copies of this gene located within a cluster of chemokine genes on chromosome 17q. [provided by RefSeq, Apr 2009]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 36165624 - 36264527

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000274808 (version 83.38)

Entrez gene

 414059

UniProt

 A6NDS4 (UniProt - Evidence at transcript level)

neXtProt

 NX_A6NDS4

Antibodypedia

 TBC1D3B antibodies

PROTEIN BROWSER
TBC1D3B-001
TBC1D3B-004
TBC1D3B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBC1D3B-001
ENSP00000478473
ENST00000611257
A6NDS4 [Direct mapping]
TBC1 domain family member 3B
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005096 [GTPase activator activity]
GO:0005886 [plasma membrane]
GO:0043547 [positive regulation of GTPase activity]
Show all
 549 aa
62.3 kDa 		No 1
TBC1D3B-004
ENSP00000478440
ENST00000616006
A0A087WU82 [Direct mapping]
TBC1 domain family member 3B
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Predicted intracellular proteins
Show all
 49 aa
5.9 kDa 		No 0
TBC1D3B-201
ENSP00000484556
ENST00000615673
A6NDS4 [Direct mapping]
TBC1 domain family member 3B
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005096 [GTPase activator activity]
GO:0005886 [plasma membrane]
GO:0043547 [positive regulation of GTPase activity]
Show all
 549 aa
62.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.