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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AATF
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AATF

Gene description

Apoptosis antagonizing transcription factor

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Sub cellular location is contradicted by external data. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA004940
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA004940

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignancies showed moderate to strong cytoplasmic immunoreactivity often combined with nuclear staining.

GENE INFORMATION

Gene name

AATF (HGNC Symbol)

Synonyms

BFR2, CHE-1, CHE1, DED

Description

Apoptosis antagonizing transcription factor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q12

Chromosome location (bp)

36948875 - 37056871

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000275700 (version 83.38)

Entrez gene

26574

UniProt

Q9NY61 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NY61

Antibodypedia

AATF antibodies

PROTEIN BROWSER

AATF-001
AATF-006
AATF-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AATF-001
ENSP00000477848
ENST00000619387
Q9NY61 [Direct mapping]
Protein AATF
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005925 [focal adhesion]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007155 [cell adhesion]
GO:0007346 [regulation of mitotic cell cycle]
GO:0019904 [protein domain specific binding]
GO:0032929 [negative regulation of superoxide anion generation]
GO:0040016 [embryonic cleavage]
GO:0042254 [ribosome biogenesis]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0097190 [apoptotic signaling pathway]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
560 aa
63.1 kDa
No 0
AATF-006
ENSP00000480472
ENST00000610798
A0A087WWS8 [Direct mapping]
Protein AATF
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
Show all
154 aa
17.8 kDa
No 0
AATF-007
ENSP00000477881
ENST00000616434
A0A087WTH8 [Direct mapping]
Protein AATF
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
Show all
98 aa
11.3 kDa
No 0

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