Cell atlas - ARHGAP23 - The Human Protein Atlas

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ARHGAP23

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ARHGAP23
Gene description	Rho GTPase activating protein 23
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Plasma membrane (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA019818 , HPA047291
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved), Plasma membrane (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA019818	A-431	Nucleoplasm
		Plasma membrane
		Cytosol
HPA019818	U-2 OS	Nucleoplasm
		Plasma membrane
		Cytosol
HPA019818	U-251 MG	Nucleoplasm
HPA019818	U-251 MG	Plasma membrane
HPA047291	HeLa	Nucleoplasm
HPA047291	U-2 OS	Nucleus
HPA047291	U-251 MG	No staining

GENE INFORMATION
Gene name	ARHGAP23 (HGNC Symbol)
Synonyms	KIAA1501
Description	Rho GTPase activating protein 23 (HGNC Symbol)
Entrez gene summary	The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	38419280 - 38512392
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000275832 (version 83.38)
Entrez gene	57636
UniProt	Q9P227 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P227
Antibodypedia	ARHGAP23 antibodies

PROTEIN BROWSER

ARHGAP23-001	ARHGAP23-002	ARHGAP23-004	ARHGAP23-005	ARHGAP23-006	ARHGAP23-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP23-001 ENSP00000482992 ENST00000620417	Q9P227 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0070062 [extracellular exosome] Show all	1144 aa 125.7 kDa	No	0
ARHGAP23-002 ENSP00000482982 ENST00000618942	A0A087WZZ2 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	102 aa 11.3 kDa	No	0
ARHGAP23-004 ENSP00000484509 ENST00000614693	A0A087X1W6 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all		64 aa 6.8 kDa	No	0
ARHGAP23-005 ENSP00000478142 ENST00000620329	A0A087WTU4 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all	GO:0007165 [signal transduction] Show all	136 aa 15.5 kDa	No	0
ARHGAP23-006 ENSP00000481862 ENST00000622683	Q9P227 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0070062 [extracellular exosome] Show all	1491 aa 162.2 kDa	No	0
ARHGAP23-008 ENSP00000481292 ENST00000616909	A0A087WXU2 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all		163 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.