Expression of ARHGAP23 in cancer - Summary - The Human Protein Atlas

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ARHGAP23

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARHGAP23
Gene description	Rho GTPase activating protein 23
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HaCaT)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA019818
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019818

GENE INFORMATION
Gene name	ARHGAP23 (HGNC Symbol)
Synonyms	KIAA1501
Description	Rho GTPase activating protein 23 (HGNC Symbol)
Entrez gene summary	The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	38419280 - 38512392
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000275832 (version 83.38)
Entrez gene	57636
UniProt	Q9P227 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P227
Antibodypedia	ARHGAP23 antibodies

PROTEIN BROWSER

ARHGAP23-001	ARHGAP23-002	ARHGAP23-004	ARHGAP23-005	ARHGAP23-006	ARHGAP23-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP23-001 ENSP00000482992 ENST00000620417	Q9P227 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0070062 [extracellular exosome] Show all	1144 aa 125.7 kDa	No	0
ARHGAP23-002 ENSP00000482982 ENST00000618942	A0A087WZZ2 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	102 aa 11.3 kDa	No	0
ARHGAP23-004 ENSP00000484509 ENST00000614693	A0A087X1W6 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all		64 aa 6.8 kDa	No	0
ARHGAP23-005 ENSP00000478142 ENST00000620329	A0A087WTU4 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all	GO:0007165 [signal transduction] Show all	136 aa 15.5 kDa	No	0
ARHGAP23-006 ENSP00000481862 ENST00000622683	Q9P227 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0070062 [extracellular exosome] Show all	1491 aa 162.2 kDa	No	0
ARHGAP23-008 ENSP00000481292 ENST00000616909	A0A087WXU2 [Direct mapping] Rho GTPase-activating protein 23 Show all	Predicted intracellular proteins Show all		163 aa 17.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.