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PIP4K2B

GENERAL INFORMATION

Gene name

 PIP4K2B

Gene description

 Phosphatidylinositol-5-phosphate 4-kinase, type II, beta

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA047875
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PIP4K2B (HGNC Symbol)

Synonyms

 PIP5K2B, PIP5KIIB, PIP5KIIbeta

Description

 Phosphatidylinositol-5-phosphate 4-kinase, type II, beta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 38765689 - 38800126

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000276293 (version 83.38)

Entrez gene

 8396

UniProt

 P78356 (UniProt - Evidence at protein level)

neXtProt

 NX_P78356

Antibodypedia

 PIP4K2B antibodies

PROTEIN BROWSER
PIP4K2B-001
PIP4K2B-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIP4K2B-001
ENSP00000482548
ENST00000619039
P78356 [Direct mapping]
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005776 [autophagosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010506 [regulation of autophagy]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016308 [1-phosphatidylinositol-4-phosphate 5-kinase activity]
GO:0016309 [1-phosphatidylinositol-5-phosphate 4-kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:2000786 [positive regulation of autophagosome assembly]
Show all
 416 aa
47.4 kDa 		No 0
PIP4K2B-002
ENSP00000477549
ENST00000617499
A0A087WT35 [Direct mapping]
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
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Predicted intracellular proteins
Show all
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
Show all
 71 aa
8.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.