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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACACA
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACACA

Gene description

Acetyl-CoA carboxylase alpha

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissue types, including adipocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 2 antibodies.
HPA063018 , CAB013715
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA063018
CAB013715

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers showed moderate to strong cytoplasmic positivity. Cases of gliomas and testis cancers displayed weak staining or were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers displayed moderate cytoplasmic staining. A majority of lymphomas showed weak positivity.

GENE INFORMATION

Gene name

ACACA (HGNC Symbol)

Synonyms

ACAC, ACC, ACC1

Description

Acetyl-CoA carboxylase alpha (HGNC Symbol)

Entrez gene summary

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q12

Chromosome location (bp)

37084988 - 37406818

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000278540 (version 83.38)

Entrez gene

31

UniProt

Q13085 (UniProt - Evidence at protein level)

neXtProt

NX_Q13085

Antibodypedia

ACACA antibodies

PROTEIN BROWSER

ACACA-001
ACACA-002
ACACA-003
ACACA-004
ACACA-008
ACACA-009
ACACA-012
ACACA-018
ACACA-019
ACACA-025

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACACA-001
ENSP00000483300
ENST00000616317
Q13085 [Direct mapping]
Acetyl-CoA carboxylase 1 Biotin carboxylase
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001894 [tissue homeostasis]
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0015629 [actin cytoskeleton]
GO:0016874 [ligase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044268 [multicellular organismal protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0055088 [lipid homeostasis]
GO:0070062 [extracellular exosome]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:2001295 [malonyl-CoA biosynthetic process]
Show all
2383 aa
270 kDa
No 0
ACACA-002
ENSP00000482269
ENST00000612895
Q13085 [Direct mapping]
Acetyl-CoA carboxylase 1 Biotin carboxylase
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0015629 [actin cytoskeleton]
GO:0016874 [ligase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:2001295 [malonyl-CoA biosynthetic process]
Show all
2288 aa
259.7 kDa
No 0
ACACA-003
ENSP00000482368
ENST00000617649
Q13085 [Direct mapping]
Acetyl-CoA carboxylase 1 Biotin carboxylase
A0A024R0Y2 [Target identity:100%; Query identity:100%]
HCG30204, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0015629 [actin cytoskeleton]
GO:0016874 [ligase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:2001295 [malonyl-CoA biosynthetic process]
Show all
2268 aa
257.2 kDa
No 0
ACACA-004
ENSP00000477912
ENST00000616352
A0A0C4DGT1 [Direct mapping]
Acetyl-CoA carboxylase 1
Show all
Predicted intracellular proteins
Show all
120 aa
13.1 kDa
No 0
ACACA-008
ENSP00000479621
ENST00000614789
A0A087WVR6 [Direct mapping]
Acetyl-CoA carboxylase 1
Show all
Predicted intracellular proteins
Show all
42 aa
4.7 kDa
No 0
ACACA-009
ENSP00000478547
ENST00000614428
Q13085 [Direct mapping]
Acetyl-CoA carboxylase 1 Biotin carboxylase
B2ZZ90 [Target identity:100%; Query identity:100%]
Acetyl-Coenzyme A carboxylase alpha; HCG30204, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0015629 [actin cytoskeleton]
GO:0016874 [ligase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:2001295 [malonyl-CoA biosynthetic process]
Show all
2346 aa
265.6 kDa
No 0
ACACA-012
ENSP00000483969
ENST00000619546
Q59FY4 [Direct mapping]
Acetyl-CoA carboxylase 1; Acetyl-Coenzyme A carboxylase alpha isoform 2 variant
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0005524 [ATP binding]
GO:0006633 [fatty acid biosynthetic process]
GO:0016874 [ligase activity]
Show all
998 aa
114.6 kDa
No 0
ACACA-018
ENSP00000483696
ENST00000621960
A0A087X0W4 [Direct mapping]
Acetyl-CoA carboxylase 1
Show all
Predicted intracellular proteins
Show all
GO:0004075 [biotin carboxylase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
Show all
94 aa
10.8 kDa
No 0
ACACA-019
ENSP00000483852
ENST00000614438
A0A087X126 [Direct mapping]
Acetyl-CoA carboxylase 1
Show all
Predicted intracellular proteins
Show all
112 aa
12.1 kDa
No 0
ACACA-025
ENSP00000482064
ENST00000618053
A0A087WYS8 [Direct mapping]
Acetyl-CoA carboxylase 1
Show all
Predicted intracellular proteins
Show all
96 aa
10.6 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.