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ACACA

GENERAL INFORMATION

Gene name

 ACACA

Gene description

 Acetyl-CoA carboxylase alpha

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissue types, including adipocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA063018 , CAB013715
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA063018
CAB013715

GENE INFORMATION

Gene name

 ACACA (HGNC Symbol)

Synonyms

 ACAC, ACC, ACC1

Description

 Acetyl-CoA carboxylase alpha (HGNC Symbol)

Entrez gene summary

 Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 37084988 - 37406818

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000278540 (version 83.38)

Entrez gene

 31

UniProt

 Q13085 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13085

Antibodypedia

 ACACA antibodies

PROTEIN BROWSER
ACACA-001
ACACA-002
ACACA-003
ACACA-004
ACACA-008
ACACA-009
ACACA-012
ACACA-018
ACACA-019
ACACA-025

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACACA-001
ENSP00000483300
ENST00000616317
Q13085 [Direct mapping]
Acetyl-CoA carboxylase 1 Biotin carboxylase
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001894 [tissue homeostasis]
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0015629 [actin cytoskeleton]
GO:0016874 [ligase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044268 [multicellular organismal protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0055088 [lipid homeostasis]
GO:0070062 [extracellular exosome]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:2001295 [malonyl-CoA biosynthetic process]
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 2383 aa
270 kDa 		No 0
ACACA-002
ENSP00000482269
ENST00000612895
Q13085 [Direct mapping]
Acetyl-CoA carboxylase 1 Biotin carboxylase
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0015629 [actin cytoskeleton]
GO:0016874 [ligase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:2001295 [malonyl-CoA biosynthetic process]
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 2288 aa
259.7 kDa 		No 0
ACACA-003
ENSP00000482368
ENST00000617649
Q13085 [Direct mapping]
Acetyl-CoA carboxylase 1 Biotin carboxylase
A0A024R0Y2 [Target identity:100%; Query identity:100%]
HCG30204, isoform CRA_a
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0015629 [actin cytoskeleton]
GO:0016874 [ligase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:2001295 [malonyl-CoA biosynthetic process]
Show all
 2268 aa
257.2 kDa 		No 0
ACACA-004
ENSP00000477912
ENST00000616352
A0A0C4DGT1 [Direct mapping]
Acetyl-CoA carboxylase 1
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Predicted intracellular proteins
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 120 aa
13.1 kDa 		No 0
ACACA-008
ENSP00000479621
ENST00000614789
A0A087WVR6 [Direct mapping]
Acetyl-CoA carboxylase 1
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Predicted intracellular proteins
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 42 aa
4.7 kDa 		No 0
ACACA-009
ENSP00000478547
ENST00000614428
Q13085 [Direct mapping]
Acetyl-CoA carboxylase 1 Biotin carboxylase
B2ZZ90 [Target identity:100%; Query identity:100%]
Acetyl-Coenzyme A carboxylase alpha; HCG30204, isoform CRA_b
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0015629 [actin cytoskeleton]
GO:0016874 [ligase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:2001295 [malonyl-CoA biosynthetic process]
Show all
 2346 aa
265.6 kDa 		No 0
ACACA-012
ENSP00000483969
ENST00000619546
Q59FY4 [Direct mapping]
Acetyl-CoA carboxylase 1; Acetyl-Coenzyme A carboxylase alpha isoform 2 variant
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0005524 [ATP binding]
GO:0006633 [fatty acid biosynthetic process]
GO:0016874 [ligase activity]
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 998 aa
114.6 kDa 		No 0
ACACA-018
ENSP00000483696
ENST00000621960
A0A087X0W4 [Direct mapping]
Acetyl-CoA carboxylase 1
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Predicted intracellular proteins
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GO:0004075 [biotin carboxylase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
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 94 aa
10.8 kDa 		No 0
ACACA-019
ENSP00000483852
ENST00000614438
A0A087X126 [Direct mapping]
Acetyl-CoA carboxylase 1
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Predicted intracellular proteins
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 112 aa
12.1 kDa 		No 0
ACACA-025
ENSP00000482064
ENST00000618053
A0A087WYS8 [Direct mapping]
Acetyl-CoA carboxylase 1
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Predicted intracellular proteins
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 96 aa
10.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.