The Human Protein Atlas

Image of the week - FDXR by solartech0

2016-06-10
Citizen Science Image of the week Mitochondria Project Discovery Subcell Atlas

Figure 1. Staining of FDXR (green) with DNA (blue) and microtubules (red) in A549 cells.

Welcome to HPA image of the week! This week's image was brought to us by citizen scientists in Project Discovery, and specifically by solartech0 who found this image while playing Project Discovery in EVE online.

The protein stained in Fig 1. is an image of ferredoxin reductase (FDXR) found in the mitochondria of the cell. This sample shows a staining of FDXR in A549 adenocarcinomic alveolar basal epithelial cells.

FDXR is a protein involved in cellular metabolism. This process is what provides energy for our cells and is carried out in the mitochondria of the cell...Read more

Image of the week - Moesin & siRNA from x Truf

2016-06-03
Citizen Science Image of the week Plasma membrane Project Discovery Subcell Atlas

Figure 1. Staining of MSN (green) with DNA (blue) and microtubules (red) in U-251 MG cells. S

It's time for another HPA image of the week! This week's image was brought to us by citizen scientists in Project Discovery, and specifically by x Truf a member of the Signal Cartel in EVE online who found this image while playing Project Discovery.

The protein stained in Fig 1. is an image of Moesin (MSN) found in the plasma membrane of the cell. This sample shows a staining of MSN in U-251 MG human glioblastoma astrocytoma (brain) cells.

MSN is a member of the ERM family which provide a link between plasma membranes and actin filaments. This link was briefly discussed in a previous blog...Read more

Image of the week - Focal Adhesions by Shiverwarp

2016-05-20
Citizen Science Focal Adhesions Image of the week Project Discovery Subcell Atlas

Staining of CORO2B (green) with tubules (red) and DNA (blue) in U-251 MG cells.

Welcome to another HPA image of the week! This week's image was brought to us by citizen scientists in Project Discovery, and specifically by Shiverwarp who found this image while playing Project Discovery in EVE online.

The protein stained in Fig 1. is an image of Coronin, actin binding protein, 2B (CORO2B) found in the focal adhesions and at the plasma membrane of the cell. This sample shows U-251 MG human glioblastoma astrocytoma (brain) cells.

Focal adhesions are transmembrane groups of protein that allow the cell to "grab" the surrounding environment...Read more

Image of the week - Nuclear speckles, Selphentine

2016-05-13
Citizen Science Image of the week Nuclear speckles Project Discovery Subcell Atlas

Fig 1. Staining of DDX39B (green) with tubules (red) and DNA (blue) in MCF-7 cells.

Welcome to another HPA image of the week! This week's image was brought to us by citizen scientists in Project Discovery, and specifically by Selphentine who pointed out several nice examples of proteins localized to "nuclear speckles". In Project Discovery, citizen scientists are refining our annotations for proteins within the nucleus by labeling these nuclear speckles, previously not annotated in the atlas.

The protein stained in Fig 1. is an image of DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) seen in the nuclear speckles. This sample shows MCF-7 cells, a human adenocarcinoma cell line from breast cancer...Read more

Image of the week - Membrane by Aleksandra Shaishi

2016-04-22
Citizen Science Image of the week Project Discovery Subcell Atlas

Fig 1. Staining of SLCA (3 & 14) (green) with tubules (red) and DNA (blue) in CACO-2 cells. This image was taken directly as posted by Aleksandra Shaishi and thus color-channel toggles can be seen at the bottom of the image.

It's the end of the week, and that means another HPA image of the week! This week's image was brought to us by citizen scientists in Project Discovery, and specifically by Aleksandra Shaishi who found this image playing Project Discovery.

The protein labeled in Fig 1. is an image of the antibody HPA006539, which labels solute carrier family 2 (facilitated glucose transporter) (SLC2A) member 3 and member 14. This is what we call a "multi-targeting" antibody as it binds more than one protein...Read more