Cell atlas - DYRK4 - The Human Protein Atlas

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DYRK4

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	DYRK4
Gene description	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA028065 , HPA056073
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028065	A-431	Vesicles
	HPA028065	U-2 OS	No staining
	HPA028065	U-251 MG	Vesicles
	HPA056073	A-431	No staining
	HPA056073	MCF7	Vesicles	Intensity
	HPA056073	U-2 OS	Vesicles

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000030345 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA028065	NIH 3T3	No staining

GENE INFORMATION
Gene name	DYRK4
Synonyms
Description	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Chromosome	12
Cytoband	p13.32
Chromosome location (bp)	4562204 - 4615302
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010219 (version 83.38)
Entrez gene	8798
UniProt	Q9NR20 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR20
Antibodypedia	DYRK4 antibodies

PROTEIN BROWSER

DYRK4-001	DYRK4-003	DYRK4-014	DYRK4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DYRK4-001 ENSP00000441755 ENST00000540757	Q9NR20 [Direct mapping] Dual specificity tyrosine-phosphorylation-regulated kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] Show all	520 aa 59.6 kDa	No	0
DYRK4-003 ENSP00000439697 ENST00000543431	A0A0A0MTH5 [Direct mapping] Dual-specificity tyrosine-phosphorylation-regulated kinase 4 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	634 aa 72.5 kDa	No	0
DYRK4-014 ENSP00000438769 ENST00000544671	H0YFI4 [Direct mapping] Dual-specificity tyrosine-phosphorylation-regulated kinase 4 Show all	Predicted intracellular proteins Show all		120 aa 13.8 kDa	No	0
DYRK4-201 ENSP00000010132 ENST00000010132	Q9NR20 [Direct mapping] Dual specificity tyrosine-phosphorylation-regulated kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] Show all	520 aa 59.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.