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DYRK4

GENERAL INFORMATION

Gene name

 DYRK4

Gene description

 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA028065 , HPA056073
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028065
HPA056073

GENE INFORMATION

Gene name

 DYRK4

Synonyms

Description

 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

Chromosome

 12

Cytoband

 p13.32

Chromosome location (bp)

 4562204 - 4615302

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000010219 (version 83.38)

Entrez gene

 8798

UniProt

 Q9NR20 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR20

Antibodypedia

 DYRK4 antibodies

PROTEIN BROWSER
DYRK4-001
DYRK4-003
DYRK4-014
DYRK4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DYRK4-001
ENSP00000441755
ENST00000540757
Q9NR20 [Direct mapping]
Dual specificity tyrosine-phosphorylation-regulated kinase 4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
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 520 aa
59.6 kDa 		No 0
DYRK4-003
ENSP00000439697
ENST00000543431
A0A0A0MTH5 [Direct mapping]
Dual-specificity tyrosine-phosphorylation-regulated kinase 4
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   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 634 aa
72.5 kDa 		No 0
DYRK4-014
ENSP00000438769
ENST00000544671
H0YFI4 [Direct mapping]
Dual-specificity tyrosine-phosphorylation-regulated kinase 4
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Predicted intracellular proteins
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 120 aa
13.8 kDa 		No 0
DYRK4-201
ENSP00000010132
ENST00000010132
Q9NR20 [Direct mapping]
Dual specificity tyrosine-phosphorylation-regulated kinase 4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
Show all
 520 aa
59.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.