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ANLN

GENERAL INFORMATION

Gene name

 ANLN

Gene description

 Anillin actin binding protein

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (hippocampus, hypothalamus)
FANTOM5:Tissue enhanced (brain, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues, often in a subset of cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 5 antibodies.
HPA005680 , HPA050556 , CAB033902 , CAB062547 , CAB068175
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION

Gene name

 ANLN (HGNC Symbol)

Synonyms

 ANILLIN, scra, Scraps

Description

 Anillin actin binding protein (HGNC Symbol)

Entrez gene summary

 This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Chromosome

 7

Cytoband

 p14.2

Chromosome location (bp)

 36389806 - 36453791

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011426 (version 83.38)

Entrez gene

 54443

UniProt

 Q9NQW6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQW6

Antibodypedia

 ANLN antibodies

PROTEIN BROWSER
ANLN-001
ANLN-002
ANLN-004
ANLN-005
ANLN-009
ANLN-012
ANLN-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANLN-001
ENSP00000265748
ENST00000265748
Q9NQW6 [Direct mapping]
Actin-binding protein anillin
A0A024RA49 [Target identity:100%; Query identity:100%]
Anillin, actin binding protein (Scraps homolog, Drosophila), isoform CRA_e
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0000921 [septin ring assembly]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005826 [actomyosin contractile ring]
GO:0007067 [mitotic nuclear division]
GO:0007096 [regulation of exit from mitosis]
GO:0015629 [actin cytoskeleton]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0090521 [glomerular visceral epithelial cell migration]
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 1124 aa
124.2 kDa 		No 0
ANLN-002
ENSP00000379380
ENST00000396068
Q9NQW6 [Direct mapping]
Actin-binding protein anillin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0000921 [septin ring assembly]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005826 [actomyosin contractile ring]
GO:0007067 [mitotic nuclear division]
GO:0007096 [regulation of exit from mitosis]
GO:0015629 [actin cytoskeleton]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0090521 [glomerular visceral epithelial cell migration]
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 1087 aa
120 kDa 		No 0
ANLN-004
ENSP00000404979
ENST00000424865
C9JJT6 [Direct mapping]
Actin-binding protein anillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 169 aa
18.2 kDa 		No 0
ANLN-005
ENSP00000406584
ENST00000418118
C9J0G4 [Direct mapping]
Actin-binding protein anillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 36 aa
3.8 kDa 		No 0
ANLN-009
ENSP00000413522
ENST00000428612
H7C3S1 [Direct mapping]
Actin-binding protein anillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 236 aa
26.6 kDa 		No 0
ANLN-012
ENSP00000400777
ENST00000446635
H7C1K5 [Direct mapping]
Actin-binding protein anillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 277 aa
30.8 kDa 		No 0
ANLN-013
ENSP00000399553
ENST00000457743
H7C1C2 [Direct mapping]
Actin-binding protein anillin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 252 aa
27.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.