Expression of DCN in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DCN
Gene description	Decorin
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	19
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (ASC TERT1, BJ, BJ hTERT+, U-2197)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly extracellular positivity in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 4 antibodies. HPA003315 , HPA064736 , CAB017118 , CAB068930
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA003315	HPA064736	CAB017118	CAB068930

GENE INFORMATION
Gene name	DCN (HGNC Symbol)
Synonyms	DSPG2, SLRR1B
Description	Decorin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
Chromosome	12
Cytoband	q21.33
Chromosome location (bp)	91140484 - 91183123
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011465 (version 83.38)
Entrez gene	1634
UniProt	P07585 (UniProt - Evidence at protein level)
neXtProt	NX_P07585
Antibodypedia	DCN antibodies

PROTEIN BROWSER

DCN-001	DCN-002	DCN-004	DCN-005	DCN-006	DCN-007	DCN-008	DCN-009	DCN-010	DCN-011	DCN-012	DCN-013	DCN-014	DCN-015	DCN-016	DCN-017	DCN-018	DCN-201	DCN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCN-001 ENSP00000052754 ENST00000052754	P07585 [Direct mapping] Decorin Q6FH10 [Target identity:100%; Query identity:100%] DCN protein; Decorin, isoform CRA_b; Putative uncharacterized protein DKFZp686J19238; cDNA FLJ75936, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0001890 [placenta development] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005589 [collagen type VI trimer] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0007519 [skeletal muscle tissue development] GO:0007568 [aging] GO:0009612 [response to mechanical stimulus] GO:0009887 [organ morphogenesis] GO:0010508 [positive regulation of autophagy] GO:0019800 [peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0031012 [extracellular matrix] GO:0032496 [response to lipopolysaccharide] GO:0042060 [wound healing] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0047485 [protein N-terminus binding] GO:0050840 [extracellular matrix binding] Show all	359 aa 39.7 kDa	Yes	0
DCN-002 ENSP00000447654 ENST00000552962	P07585 [Direct mapping] Decorin Q6FH10 [Target identity:100%; Query identity:100%] DCN protein; Decorin, isoform CRA_b; Putative uncharacterized protein DKFZp686J19238; cDNA FLJ75936, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0009887 [organ morphogenesis] GO:0010508 [positive regulation of autophagy] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0031012 [extracellular matrix] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] Show all	359 aa 39.7 kDa	Yes	0
DCN-004 ENSP00000448857 ENST00000546745	F8VU58 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] Show all	98 aa 11.2 kDa	Yes	0
DCN-005 ENSP00000448274 ENST00000551354	F8VSI3 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] Show all	100 aa 11.2 kDa	Yes	0
DCN-006 ENSP00000447674 ENST00000547568	P07585 [Direct mapping] Decorin A0A024RBG6 [Target identity:100%; Query identity:100%] Decorin, isoform CRA_f Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0009887 [organ morphogenesis] GO:0010508 [positive regulation of autophagy] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0031012 [extracellular matrix] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] Show all	212 aa 23.3 kDa	Yes	0
DCN-007 ENSP00000446530 ENST00000546391	F8VNV6 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005518 [collagen binding] Show all	177 aa 19.3 kDa	Yes	0
DCN-008 ENSP00000449782 ENST00000547937	F8VWU0 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005518 [collagen binding] Show all	179 aa 20.2 kDa	Yes	0
DCN-009 ENSP00000449438 ENST00000549513	F8VX58 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005518 [collagen binding] Show all	119 aa 13.3 kDa	Yes	0
DCN-010 ENSP00000448057 ENST00000550099	F8VU58 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] Show all	98 aa 11.2 kDa	Yes	0
DCN-011 ENSP00000449014 ENST00000550563	F8VXZ8 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005518 [collagen binding] Show all	174 aa 19.6 kDa	Yes	0
DCN-012 ENSP00000446527 ENST00000546370	F8VNW0 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] Show all	88 aa 9.8 kDa	Yes	0
DCN-013 ENSP00000449408 ENST00000550758	H0YIH3 [Direct mapping] Decorin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005518 [collagen binding] Show all	95 aa 10.2 kDa	No	0
DCN-014 ENSP00000448853 ENST00000548218	H0YI87 [Direct mapping] Decorin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] Show all	52 aa 5.8 kDa	No	0
DCN-015 ENSP00000399815 ENST00000441303	P07585 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0009887 [organ morphogenesis] GO:0010508 [positive regulation of autophagy] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0031012 [extracellular matrix] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] Show all	172 aa 19.2 kDa	Yes	0
DCN-016 ENSP00000447886 ENST00000552145	F8VUF6 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005518 [collagen binding] Show all	178 aa 20.1 kDa	Yes	0
DCN-017 ENSP00000398514 ENST00000456569	P07585 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0009887 [organ morphogenesis] GO:0010508 [positive regulation of autophagy] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0031012 [extracellular matrix] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] Show all	75 aa 8.3 kDa	Yes	0
DCN-018 ENSP00000413723 ENST00000420120	P07585 [Direct mapping] Decorin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0009887 [organ morphogenesis] GO:0010508 [positive regulation of autophagy] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0031012 [extracellular matrix] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] Show all	250 aa 27.4 kDa	Yes	0
DCN-201 ENSP00000376862 ENST00000393155	P07585 [Direct mapping] Decorin Q6FH10 [Target identity:100%; Query identity:100%] DCN protein; Decorin, isoform CRA_b; Putative uncharacterized protein DKFZp686J19238; cDNA FLJ75936, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0009887 [organ morphogenesis] GO:0010508 [positive regulation of autophagy] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0031012 [extracellular matrix] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] Show all	359 aa 39.7 kDa	Yes	0
DCN-202 ENSP00000401021 ENST00000425043	P07585 [Direct mapping] Decorin A0A024RBG6 [Target identity:100%; Query identity:100%] Decorin, isoform CRA_f Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0009887 [organ morphogenesis] GO:0010508 [positive regulation of autophagy] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0031012 [extracellular matrix] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] Show all	212 aa 23.3 kDa	Yes	0