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DCN

GENERAL INFORMATION

Gene name

 DCN

Gene description

 Decorin

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 19
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly extracellular positivity in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 4 antibodies.
HPA003315 , HPA064736 , CAB017118 , CAB068930
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Soft tissue

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DCN (HGNC Symbol)

Synonyms

 DSPG2, SLRR1B

Description

 Decorin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

Chromosome

 12

Cytoband

 q21.33

Chromosome location (bp)

 91140484 - 91183123

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011465 (version 83.38)

Entrez gene

 1634

UniProt

 P07585 (UniProt - Evidence at protein level)

neXtProt

 NX_P07585

Antibodypedia

 DCN antibodies

PROTEIN BROWSER
«
DCN-001
DCN-002
DCN-004
DCN-005
DCN-006
DCN-007
DCN-008
DCN-009
DCN-010
DCN-011
DCN-012
DCN-013
DCN-014
DCN-015
DCN-016
DCN-017
DCN-018
DCN-201
DCN-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCN-001
ENSP00000052754
ENST00000052754
P07585 [Direct mapping]
Decorin
Q6FH10 [Target identity:100%; Query identity:100%]
DCN protein; Decorin, isoform CRA_b; Putative uncharacterized protein DKFZp686J19238; cDNA FLJ75936, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001890 [placenta development]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005589 [collagen type VI trimer]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0007519 [skeletal muscle tissue development]
GO:0007568 [aging]
GO:0009612 [response to mechanical stimulus]
GO:0009887 [organ morphogenesis]
GO:0010508 [positive regulation of autophagy]
GO:0019800 [peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0031012 [extracellular matrix]
GO:0032496 [response to lipopolysaccharide]
GO:0042060 [wound healing]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0047485 [protein N-terminus binding]
GO:0050840 [extracellular matrix binding]
Show all
 359 aa
39.7 kDa 		Yes 0
DCN-002
ENSP00000447654
ENST00000552962
P07585 [Direct mapping]
Decorin
Q6FH10 [Target identity:100%; Query identity:100%]
DCN protein; Decorin, isoform CRA_b; Putative uncharacterized protein DKFZp686J19238; cDNA FLJ75936, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0009887 [organ morphogenesis]
GO:0010508 [positive regulation of autophagy]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 359 aa
39.7 kDa 		Yes 0
DCN-004
ENSP00000448857
ENST00000546745
F8VU58 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005518 [collagen binding]
Show all
 98 aa
11.2 kDa 		Yes 0
DCN-005
ENSP00000448274
ENST00000551354
F8VSI3 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005518 [collagen binding]
Show all
 100 aa
11.2 kDa 		Yes 0
DCN-006
ENSP00000447674
ENST00000547568
P07585 [Direct mapping]
Decorin
A0A024RBG6 [Target identity:100%; Query identity:100%]
Decorin, isoform CRA_f
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0009887 [organ morphogenesis]
GO:0010508 [positive regulation of autophagy]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 212 aa
23.3 kDa 		Yes 0
DCN-007
ENSP00000446530
ENST00000546391
F8VNV6 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
Show all
 177 aa
19.3 kDa 		Yes 0
DCN-008
ENSP00000449782
ENST00000547937
F8VWU0 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
Show all
 179 aa
20.2 kDa 		Yes 0
DCN-009
ENSP00000449438
ENST00000549513
F8VX58 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
Show all
 119 aa
13.3 kDa 		Yes 0
DCN-010
ENSP00000448057
ENST00000550099
F8VU58 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005518 [collagen binding]
Show all
 98 aa
11.2 kDa 		Yes 0
DCN-011
ENSP00000449014
ENST00000550563
F8VXZ8 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
Show all
 174 aa
19.6 kDa 		Yes 0
DCN-012
ENSP00000446527
ENST00000546370
F8VNW0 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005518 [collagen binding]
Show all
 88 aa
9.8 kDa 		Yes 0
DCN-013
ENSP00000449408
ENST00000550758
H0YIH3 [Direct mapping]
Decorin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
Show all
 95 aa
10.2 kDa 		No 0
DCN-014
ENSP00000448853
ENST00000548218
H0YI87 [Direct mapping]
Decorin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005518 [collagen binding]
Show all
 52 aa
5.8 kDa 		No 0
DCN-015
ENSP00000399815
ENST00000441303
P07585 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0009887 [organ morphogenesis]
GO:0010508 [positive regulation of autophagy]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 172 aa
19.2 kDa 		Yes 0
DCN-016
ENSP00000447886
ENST00000552145
F8VUF6 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
Show all
 178 aa
20.1 kDa 		Yes 0
DCN-017
ENSP00000398514
ENST00000456569
P07585 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0009887 [organ morphogenesis]
GO:0010508 [positive regulation of autophagy]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 75 aa
8.3 kDa 		Yes 0
DCN-018
ENSP00000413723
ENST00000420120
P07585 [Direct mapping]
Decorin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0009887 [organ morphogenesis]
GO:0010508 [positive regulation of autophagy]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 250 aa
27.4 kDa 		Yes 0
DCN-201
ENSP00000376862
ENST00000393155
P07585 [Direct mapping]
Decorin
Q6FH10 [Target identity:100%; Query identity:100%]
DCN protein; Decorin, isoform CRA_b; Putative uncharacterized protein DKFZp686J19238; cDNA FLJ75936, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0009887 [organ morphogenesis]
GO:0010508 [positive regulation of autophagy]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 359 aa
39.7 kDa 		Yes 0
DCN-202
ENSP00000401021
ENST00000425043
P07585 [Direct mapping]
Decorin
A0A024RBG6 [Target identity:100%; Query identity:100%]
Decorin, isoform CRA_f
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0009887 [organ morphogenesis]
GO:0010508 [positive regulation of autophagy]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 212 aa
23.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.