Expression of MVP in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MVP
Gene description	Major vault protein
Protein class	Cancer-related genes Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and cases of membranous expression in several tissues, most abundant in gastrointestinal and respiratory tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 4 antibodies. HPA002321 , HPA064740 , CAB002752 , CAB022717
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002321	HPA064740	CAB002752	CAB022717

GENE INFORMATION
Gene name	MVP (HGNC Symbol)
Synonyms	LRP, VAULT1
Description	Major vault protein (HGNC Symbol)
Entrez gene summary	This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	29820394 - 29848039
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000013364 (version 83.38)
Entrez gene	9961
UniProt	Q14764 (UniProt - Evidence at protein level)
neXtProt	NX_Q14764
Antibodypedia	MVP antibodies

PROTEIN BROWSER

MVP-001	MVP-002	MVP-009	MVP-010	MVP-011	MVP-016	MVP-018	MVP-201	MVP-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MVP-001 ENSP00000349977 ENST00000357402	Q14764 [Direct mapping] Major vault protein X5D2M8 [Target identity:100%; Query identity:100%] Major vault protein isoform A; Major vault protein, isoform CRA_c Show all	Transporters Transporter channels and pores Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0023057 [negative regulation of signaling] GO:0030529 [ribonucleoprotein complex] GO:0031953 [negative regulation of protein autophosphorylation] GO:0038127 [ERBB signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0051028 [mRNA transport] GO:0061099 [negative regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] Show all	893 aa 99.3 kDa	No	0
MVP-002 ENSP00000455819 ENST00000563915	H3BQK6 [Direct mapping] Major vault protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		220 aa 25.1 kDa	No	0
MVP-009 ENSP00000454819 ENST00000565164	H3BNF2 [Direct mapping] Major vault protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 5 kDa	No	0
MVP-010 ENSP00000456291 ENST00000570234	H3BRL2 [Direct mapping] Major vault protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.9 kDa	No	0
MVP-011 ENSP00000455186 ENST00000566066	H3BP76 [Direct mapping] Major vault protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.9 kDa	No	0
MVP-016 ENSP00000457685 ENST00000566252	H3BUK7 [Direct mapping] Major vault protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 12.4 kDa	No	0
MVP-018 ENSP00000454825 ENST00000563558	H3BNF6 [Direct mapping] Major vault protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 16.5 kDa	No	0
MVP-201 ENSP00000378760 ENST00000395353	Q14764 [Direct mapping] Major vault protein X5D2M8 [Target identity:100%; Query identity:100%] Major vault protein isoform A; Major vault protein, isoform CRA_c Show all	Transporters Transporter channels and pores Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0023057 [negative regulation of signaling] GO:0030529 [ribonucleoprotein complex] GO:0031953 [negative regulation of protein autophosphorylation] GO:0038127 [ERBB signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0051028 [mRNA transport] GO:0061099 [negative regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] Show all	893 aa 99.3 kDa	No	0
MVP-202 ENSP00000486166 ENST00000629059	H3BPZ2 [Direct mapping] Major vault protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		39 aa 4.5 kDa	No	0