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MVP

GENERAL INFORMATION

Gene name

 MVP

Gene description

 Major vault protein

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and cases of membranous expression in several tissues, most abundant in gastrointestinal and respiratory tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 4 antibodies.
HPA002321 , HPA064740 , CAB002752 , CAB022717
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MVP (HGNC Symbol)

Synonyms

 LRP, VAULT1

Description

 Major vault protein (HGNC Symbol)

Entrez gene summary

 This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 29820394 - 29848039

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000013364 (version 83.38)

Entrez gene

 9961

UniProt

 Q14764 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14764

Antibodypedia

 MVP antibodies

PROTEIN BROWSER
MVP-001
MVP-002
MVP-009
MVP-010
MVP-011
MVP-016
MVP-018
MVP-201
MVP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MVP-001
ENSP00000349977
ENST00000357402
Q14764 [Direct mapping]
Major vault protein
X5D2M8 [Target identity:100%; Query identity:100%]
Major vault protein isoform A; Major vault protein, isoform CRA_c
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0023057 [negative regulation of signaling]
GO:0030529 [ribonucleoprotein complex]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0038127 [ERBB signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051028 [mRNA transport]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070062 [extracellular exosome]
Show all
 893 aa
99.3 kDa 		No 0
MVP-002
ENSP00000455819
ENST00000563915
H3BQK6 [Direct mapping]
Major vault protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 220 aa
25.1 kDa 		No 0
MVP-009
ENSP00000454819
ENST00000565164
H3BNF2 [Direct mapping]
Major vault protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 42 aa
5 kDa 		No 0
MVP-010
ENSP00000456291
ENST00000570234
H3BRL2 [Direct mapping]
Major vault protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 149 aa
16.9 kDa 		No 0
MVP-011
ENSP00000455186
ENST00000566066
H3BP76 [Direct mapping]
Major vault protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 94 aa
10.9 kDa 		No 0
MVP-016
ENSP00000457685
ENST00000566252
H3BUK7 [Direct mapping]
Major vault protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 107 aa
12.4 kDa 		No 0
MVP-018
ENSP00000454825
ENST00000563558
H3BNF6 [Direct mapping]
Major vault protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
16.5 kDa 		No 0
MVP-201
ENSP00000378760
ENST00000395353
Q14764 [Direct mapping]
Major vault protein
X5D2M8 [Target identity:100%; Query identity:100%]
Major vault protein isoform A; Major vault protein, isoform CRA_c
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0023057 [negative regulation of signaling]
GO:0030529 [ribonucleoprotein complex]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0038127 [ERBB signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051028 [mRNA transport]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070062 [extracellular exosome]
Show all
 893 aa
99.3 kDa 		No 0
MVP-202
ENSP00000486166
ENST00000629059
H3BPZ2 [Direct mapping]
Major vault protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 39 aa
4.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.